In 1980, at the age of fourteen, she was spotted by a friend of Malcolm McLaren singing at a dry cleaning premises in North London where she worked part-time. Following her successful audition for the lead singer position in McLaren's new group (the yet-to-be-named band Bow Wow Wow). The group would go on to chart success with the songs "Go Wild in the Country", "Do You Wanna Hold Me?" and "I Want Candy". Lwin later caused controversy the following year by posing nude for the cover of See Jungle! See Jungle! Go Join Your Gang, Yeah. City All Over! Go Ape Crazy, the group's first full-length album.
When Lwin was ousted from the band in September 1983 following the release of their final album,] she embarked on a solo career, releasing the album Fever in 1986, which was produced by and recorded with multi-instrumentalist Jim Lea of Slade. She formed a new band, Naked Experience, and collaborated across the Atlantic with seasoned musicians and songwriters such as Billy Steinberg and Ellen Shipley.
Lwin reunited with the former bass player from Bow Wow Wow in 1997, recreating the sound of the original band for a US tour. The reunion included appearances by a range of musicians from the young up and coming, such as Eshan Khadaroo of Beat Kitchen, (Blue Man), and the established, including Adrian Young from (No Doubt), both playing drums in place of original member Dave Barbe. The original guitarist Matthew Ashman had died of complications from diabetes in 1995, and various guitarists filled in.
She continues to sing and perform Bow Wow Wow and new songs as well as participating in animal charity related concerts.